R (continued)
- Run Saber
- Rush 'n Attack
- Rygar
- Rygar - the Legendary Adventure
S
- S.C.A.T.
- Sagaia
- Saint Sword
- Saiyuuki World
- Samurai Pizza Cats
- SD Kidou Senshi Gundam - V Sakusen Shidou
- SD Kidou Senshi Gundam 2
- Secret of Mana
- Section Z
- Sega Rally
- Seiken Densetsu 3
- Seiken Psycho Calibur
- Sengoku
- Sengoku Denshou
- Sexy Parodius
- Shadow Blasters
- Shadow Dancer
- Shadow Hearts
- Shadow of the Colossus
- Shadow of the Ninja
- Shadowgate
- Shadowrun
- Shadowrun (SNES)
- Shatterhand
- Shien's Revenge
- Shining in the Darkness
- Shining Wisdom
- Shinobi
- Shinobi III - Return of the Ninja Master
- Shinobi Legions
- Shufflepuck Café
- Shui Hu Feng Yun Zhuan
- Silent Bomber
- Silent Hill
- Silent Hill 2
- Silent Hill 3
- Silhouette Mirage
- Silkworm
- Silpheed
- Silpheed: the Lost Planet
- Silver
- Silver Surfer
- Skeleton Krew
- Sky Shark
- SkyBlazer
- Sküljagger - Revolt of the Westicans